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Li Chen, Ph.D

Dr. Li Chen, Executive Director, and Chief Executive Officer, founded and leads Hua Medicine to discover and develop clinically differentiated medicine in China for Global. Under his leadership, Hua Medicine has successfully brought an disease modifying first-in-class glucokinase activator (GKA) HuaTangNing(华堂宁?) (dorzagliatin tablets, HMS5552) into China market. Dorzagliatin is approved by the National Medical Products Administration (NMPA) of China for Type 2 Diabetes with its unique mechanism of action in restoring the impaired glucose homeostasis. During this period, Hua Medicine raised USD 200 million from equity market and RMB 1.5 billion for commercialization milestone payment.Li received his PhD at Iowa State University and joined Roche R&D center in USA in 1992. With 18 years at Roche, Li advanced his career from a medicinal chemist to the head of High Throughput Technology, and later CSO of Roche China R&D Center with a membership at Roche Research Leadership Team. He is an inventor of 160 granted patents, 322 patent applications and an author with about 70 publications including Nature Medicine, Lancet Diabetes and Endocrinology, Diabetes, Diabetes obesity and metabolism, PNAS, JACS and JOC.

James S. MacDonald, Ph.D.

Until his retirement in 2008, James MacDonald was Executive Vice President, Preclinical Development, at Schering- Plough Research Institute. Over a 15 year period at Schering-Plough, Dr. MacDonald was responsible for directing activities surrounding the movement of new potential therapeutic entities from discovery research into and through the development process. This role encompassed all therapeutic areas as well as licensing and acquisition programs; several hundred compounds were evaluated during this tenure with dozens entering clinical trials, several currently marketed globally, and many more continuing in development. His direct line of responsibility during this tenure was for the toxicology and drug metabolism groups which built on his previous experience with Merck. In this earlier role, Dr. MacDonald spent 17 years with the Merck organization ending as Executive Director of Toxicology in the Department of Safety Assessment and, again, had extensive experience with many new molecules coming into development from discovery including many important medicines currently marketed globally. Dr. MacDonald was a member of the Board of Trustees of HESI for 15 years ending as that organizations’ President. He has served on the National Academy of Sciences National Research Council Committee on Inorganic Arsenic since its inception in 2012. Dr. MacDonald received a Ph.D. in toxicology from the University of Cincinnati and completed a post-doctoral fellowship at Vanderbilt University. In 2008, he formed Chrysalis Pharma Consulting, LLC of which he is currently the President to continue to facilitate the development of innovative new medicines with a particular focus on bringing new molecular entities from late stage lead optimization through initial human testing to clinical proof of concept. To broaden this capability, he formed Synergy Partners, R&D Solutions, LLC with Dr. Catherine Strader in 2014. As Founding Partners, Drs. MacDonald and Strader have formed a network of experienced professionals in all disciplines involved with the discovery and development of new therapeutic entities. This group is currently partnering with small and mid-sized pharmaceutical companies to bring new, innovative medicines forward to meet unmet medical needs. Dr. MacDonald continues his interest in understanding mechanisms of toxicity and in improving the process of assessment of human risk of cancer.

Bennett M. Shapiro, M.D.

Bennett M. Shapiro, M.D. is Co-Founder and Non-Executive Director of PureTech Health plc (PRTC.L). He is also Chairman of VBL therapeutics, Ltd (VBLT). From 1990 to 2003 he was Executive Vice President, Merck Research Laboratories, initially leading Worldwide Basic Research and responsible for all the basic and preclinical research activities at Merck, later Licensing and External Research, responsible for Merck’s relationships with the academic and industrial biomedical research community -- leadership resulting in the discovery, development and registration of some 25 drugs and vaccines.Earlier, he was Professor and Chairman of the Department of Biochemistry at the University of Washington. He is the author of over 120 papers on the molecular regulation of cellular behavior and the biochemical events that integrate the cascade of cellular activations at fertilization.Shapiro received his B.S. in chemistry from Dickinson College and his M.D. from Jefferson Medical College. Following an Internship in Medicine at the University of Pennsylvania Hospital, he was a Research Associate at the NIH, then a Visiting Scientist at the Institut Pasteur in Paris, and returned to the NIH as Chief - Section on Cellular Differentiation in the Laboratory of Biochemistry, prior to joining the University of Washington. Dr. Shapiro has been a Guggenheim Fellow, a Fellow of the Japan Society for the Promotion of Science and a Visiting Professor at the University of Nice. He has served on many institutional advisory boards and scientific review panels.Shapiro is also a Director of Momenta Pharmaceuticals, Vedanta Biosciences, Tal Medical, Karuna Pharma and Akili Interactive Laboratories. He also is a Director of the non-profit Drugs for Neglected Diseases initiative (DNDi), the Mind and Life Institute, and the Garrison Institute.

Ji Zhang, Ph.D.

Dr Ji Zhang, Ph.D. in Statistics, previously served as a Senior Vice President of Sanofi Research and Development Operations. He led a global team of more than 4,000 scientists in over 30 countries, and has more than 30 years of experience in innovative drug R&D operations and management in pharmaceutical industry. Dr. Ji Zhang has strategic vision and outstanding operational leadership in clinical development & operations, translational medicine, early development, investment portfolio & project management, digital strategy and implementation. He also has extensive experience in preclinical safety, synthetic and biologic CMC, and medical affairs. He has demonstrated exceptional leadership in transformational changes of enterprises, people development and team building, and global/multi-culture versatility. Dr. Ji Zhang has been extensively published in clinical development research areas with more than 100 peer reviewed scientific papers and technical reports, and has played an important leadership roles in the development and marketing of multiple innovative medicines, including Singulair?, Jevtana?, Multaq?, Toujeo?, Soliqua?, Aubagio?, Dupixent?, Praluent?, Kevzara?, Cerdelga?, Sarclisa?, among others. Dr. Ji Zhang has also achieved industry leading achievements in business model innovation, productivity enhancement and quality control.

Catherine D. Strader, Ph.D.

With more than 30 years of pharmaceutical R&D experience, Catherine Strader has expertise ranging from the selection of molecular targets through clinical proof of concept. As executive vice president of Discovery Research and Chief Scientific Officer for Schering-Plough, Catherine had both strategic and operational responsibility for the company’s global small molecule and biologics discovery research portfolio. During this time, Catherine and her team initiated many of the programs that currently populate the Merck portfolio, including the BACE inhibitor for Alzheimer’s and Zontivity? for cardiovascular disease, as well as providing early development guidance for programs ranging from biologics for inflammation to Victrelis? for HCV infection. At Merck, Catherine was responsible for developing and implementing an integrated strategy for building Merck's early pipeline using external sources of innovation and subsequently served as Site Head for Merck’s large NJ discovery research sites, with accountability for delivering the research portfolio from these areas.Catherine is currently Founding Partner at Synergy Partners R&D Solutions, where she and her colleagues consult with biopharmaceutical and venture-backed companies on both the strategic and technical aspects of building and maintaining a pipeline. The team advises client companies to guide the translation of compounds through discovery and early development, realization of an appropriate risk profile for the portfolio, and design of productive multi-partner collaborations.Catherine holds a Ph.D. in Chemistry from the California Institute of Technology and a BS in Chemistry from the University of Virginia, followed by postdoctoral training in the Lefkowitz lab at Duke. She is the author of more than 150 scientific publications.

Paul Chew, M.D.

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